Toll-Like Receptor 4 Gene Knockout Increases the Function of Exogenous Bone Marrow Stem Cells in Ischemic Brain

The present study was to investigate the effects of toll-like receptor 4 on transplanted bone marrow stem cells in ischemic brain. Focal cerebral ischemia induced by permanent occlusion middle artery gene knockout mice and wild type control mice. Bone were injected into lateral ventricle. cylinder tests, vivo image, polymerase chain reaction array, etc. applied evaluate neurological function underlying mechanisms. On 10th d after artery, ratio right limb movement group 1 significantly higher than that without injection (p<0.05). In imaging showed 3rd cells, fluorescence intensities 3 enhanced compared with 1st 7th d. There more green fluorescent protein positive sham controls Amount 3. mice, morphogenetic 2 messenger ribonucleic acid fibroblast growth factor 9 up-regulated interleukin-1-beta decreased, firstly demonstrated deficiency further increased amount intracerebroventricularly brain areas, thereby improved focal infarction. expression environment might be one molecular